Fundamentals of Biochemistry: Life at the Molecular Level
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Voet, Voet and Pratt’s Fundamentals of Biochemistry, 5th Edition addresses the enormous advances in biochemistry, particularly in the areas of structural biology and Bioinformatics, by providing a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. While continuing in its tradition of presenting complete and balanced coverage that is clearly written and relevant to human health and disease, Fundamentals of Biochemistry, 5e includes new pedagogy and enhanced visuals that provide a pathway for student learning.
The authors are careful to present new information such that it links it to existing content, ever mindful that students assimilate new information only in the proper context. The enriched assessment content in WileyPLUS Learning Space offers students the opportunity to gauge their conceptual understanding and receive immediate feedback to address misconceptions.
Voet received his B.S. in Chemistry from the California Institute of Technology in 1960, a Ph.D. in Chemistry from Harvard University in 1966 under the direction of William Lipscomb, and then did his postdoctoral research in the Biology Department at MIT with Alexander Rich. Upon completion of his postdoc in 1969, Don became a faculty member in the Chemistry Department at the University of Pennsylvania, where he taught a variety of biochemistry courses as well as general chemistry and X-ray
reacting system is equivalent to its enthalpy change. Enthalpy, like energy, heat, and work, is given units of joules. (Some commonly used units and biochemical constants and other conventions are given in Box 1-2.) Box 1-2 Perspectives in Biochemistry Biochemical Conventions Modern biochemistry generally uses Système International (SI) units, including meters (m), kilograms (kg), and seconds (s) and their derived units, for various thermodynamic and other measurements. The following lists the
of a substance is its concentration corrected for its nonideal behavior at concentrations higher than infinite dilution). The concentrations of reactants and products in most biochemical reactions are usually so low (on the order of millimolar or less) that their activities are closely approximated by their molar concentrations. Furthermore, because biochemical reactions occur near neutral pH, biochemists have adopted a somewhat different standard-state convention: 1. The activity of pure water
However, it is more or less constant among related species; for example, in mammals G ϩ C ranges from 39 to 46%. The significance of Chargaff ’s rules was not immediately appreciated, but we now know that the structural basis for the rules derives from DNA’s double-stranded nature. B DNA Forms a Double Helix The determination of the structure of DNA by James Watson and Francis Crick in 1953 is often said to mark the birth of modern molecular biology. The Watson–Crick structure of DNA not only
C3 CH 2 4 C2 5 11 CH 2 N H H2 97.1 4.7 1.95 10.64 COO2 147.2 3.9 2.20 9.31 186.2 1.1 2.46 9.41 Structural Formulaa Amino acids with nonpolar side chains Glycine COO2 Gly H C H G pK1 ␣-COOHd pK2 ␣-NH3؉d pKR Side Chaind NH1 3 Alanine Ala A COO2 H C CH3 NH1 3 Valine Val V Leucine Leu L COO2 CH 3 H C CH CH3 NH1 3 COO2 H C CH3 CH2 CH CH3 NH1 3 Isoleucine Ile I Methionine Met M COO2 CH3 H C C* CH2 NH1 3 H CH3 COO2 H C CH2 CH2 S CH3 NH1 3 Proline Pro P